Collapse and Restoration of MHC Class-I-Dependent Immune Privilege
نویسندگان
چکیده
منابع مشابه
Immune Privilege Revisited: The Roles of Neuronal MHC Class I Molecules in Brain Development and Plasticity
Ever since its initial discovery in 1948 by George Snell, major histocompatibility (MHC) complex became the focus of intense research that, due to its diverse roles, gradually extended far beyond transplantation biology. MHC class I molecules are found on virtually all nucleated cells of jawed vertebrates and are the most polymorphic molecules described to date (Cresswell et al. 2005, Solheim 1...
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PURPOSE HLA-B27 is a major histocompatibility complex class I (MHCI) allele that has been closely associated with the development of ankylosing spondylitis and acute anterior uveitis (AAU), the most common form of uveitis worldwide. We have been characterizing the phenotypes of transgenic mice carrying a human HLA-B27 allele, but that are deficient in endogenous mouse MHCI genes (H-2K(-/-) and ...
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Few studies have been conducted on the causative factors associated with the development of cancer. Infection by high risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers. HPV is capable of evading immune system and establishing persistent infections. Prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...
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Members of the major histocompatibility complex (MHC) class I family of proteins are well known for their central role in the adaptive immune system, where they present self and non-self peptides for immune surveillance. Although the brain has been long considered immune privileged, in part because of an apparent lack of neuronal MHC class I, it has since been shown that MHC class I proteins ar...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2004
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63151-3